The Journal of Pathology Biology Diagrams Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer.
Cancer stem cells and the cell cycle: targeting the drive behind breast cancer. Cancer stem cells and the cell cycle: targeting the drive behind breast cancer Expert Rev Anticancer Ther. 2009 Mar;9(3):275-9. doi: 10.1586/14737140.9.3.275. Authors Marco A Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure
The cell cycle in stem cell proliferation, pluripotency and ... Biology Diagrams
The core cell cycle machinery operating in the cell nucleus orchestrates cell division. The key components of this machinery are proteins called cyclins that bind, activate and provide substrate specificity to their associated catalytic partners, the cyclin-dependent kinases (CDKs) 1-4.Cell cycle progression can be divided into four phases: gap 1 (G1), DNA synthesis (S), gap 2 (G2) and The role of cancer stem cells in metastasis, recurrence, and resistance to conventional therapies is significant. Addressing these cells could potentially decrease cancer reoccurrences and mortality rates. TET1, a crucial gene involved in stem cell self-renewal and potency, may also play a part in cancer stem cells, which warrants further research. The duration of the cell cycle varies from one cell type to another. Most human cells complete the cycle in about 24 hours. Fast-growing cells, like those in the lining of the intestine, may complete it in just 9 or 10 hours, while liver cells take more than a year and neuronal cells take many years. The cell cycle and cancer
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor heterogeneity. Pluripotency is also linked with cell-cycle regulation because studies in mouse ESCs (mESCs) have shown that their pluripotent status is associated with a specific cell-cycle profile characterized by a shortened G1 phase and the lack of G1 checkpoint regulation (Coronado et al., 2013; Savatier et al., 1996).In conventional cells, cyclin D1-3 are expressed in G1 phase and control the activity
