Wiley Online Library Biology Diagrams In this review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells, and embryonic neural stem/progenitor cells. Cheung TH & Rando TA Molecular regulation of stem cell quiescence. Nat Understanding their function, regulation, and interactions with other cells is crucial for harnessing their therapeutic potential. Growth factors coordinate stem cell proliferation, differentiation, and survival. Epidermal growth factor (EGF) promotes neural stem cell expansion and neurogenesis. Platelet-derived growth factor (PDGF) aids
The mitochondrial pyruvate carrier MPC1 is dynamically regulated in neural stem cells (NSCs), and in vitro and in vivo genetic ablation of MPC1 leads to NSC activation. 55 Similarly, deletion of MPC1 in intestinal stem cells (ISCs) leads to increased stem cell proliferation in vivo and in vitro organoid formation. 56 In hair follicle stem cells This review will hereby focus on the role of essential fatty acids and their metabolites in the regulation of stem cell proliferation and differentiation. Essential Fatty Acid Metabolism and Cell Proliferation and Differentiation. Lipids have long been considered to be the building blocks of cellular membranes and adipose tissues as well as Stem cells are well known to be controlled transcriptionally, but recent studies indicate that pluripotency, cell fate and differentiation depend on the regulation of translation and ribosome
Concise Review: Regulation of Stem Cell Proliferation and ... Biology Diagrams
In direct conversion, cells do not necessarily transit through a defined progenitor state, 9, 37 and proliferation is not required for conversion. 38, 39, 40 However, highly proliferative cells reprogram at higher rates to both induced pluripotent stem cells (iPSCs) and post-mitotic neurons, suggesting that proliferation may serve a conserved Transcription is known to tightly regulate gene expression profiles in stem and differentiating cells, but less is known about the role of translational control. This study identifies that signals from the stem cell niche induce changes in translational rates, regulated through eIF3d1 phosphorylation, to control stem cell fate in a Drosophila testis model.
Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. The cell cycle in stem cell proliferation, pluripotency and differentiation Nat Cell Biol. 2019 Sep;21(9):1060-1067. doi: 10.1038/s41556-019-0384-4.
